Publications

CAG repeat expansions create splicing acceptor sites and produce aberrant repeat-containing RNAs
Anderson R, Das M, Chang Y, Farenhem K, Schmitz C, Jain A Molecular Cell (link)

What repeat expansion disorders can teach us about the Central Dogma
Wang E, Freudenreich C, Gromak N, Jain A. Molecular Cell (link)

Repeat-associated non-AUG translation induces cytoplasmic aggregation of CAG repeat-containing RNAs
Das M, Chang Y, Anderson R, Saunders R, Zhang N, Tomberlin C, Vale R, Jain A, Proceedings of the National Academy of Sciences, 120, Article ID e2215071120 (2023) (link)

Single-molecule analysis of specificity and multivalency in binding of short linear substrate motifs to the APC/C
Hartooni N, Sung J, Jain A, Morgan D Nature communications (link)

Osmotic Stress Triggers Phase Separation
Majumder S, Jain A Molecular Cell Preview (link)

Toward single-cell single-molecule pull-down
Wang X, Park S, Zeng L, Jain A, & Ha T, Biophysical Journal, 115, 283-288 (2018) (link)

Voltage-gated sodium channels assemble and gate as dimers
Clatot J, Hoshi M, Wan X, Liu H, Jain A, Shinlapawittayatorn K Marionneau C, Ficker E, Ha T, & Deschênes , Nature Communications, 8, Article number 2077 (2017) (link)

RNA phase transitions in repeat expansion disorders
Jain A and Vale R, Nature, 546, 243-247 (2017) (link)
News highlights by Nature, Nature Podcast, UCSF News, J Cell Biology, NSMB, Nature Chemical Biology, Nature Reviews Genetics, Nature Reviews Neurology, ALZ Forum, Faculty1000

Single-molecule analysis of lipid-protein interactions in crude cell lysates
Arauz E, Aggarwal V, Jain A, Ha T, Chen J, Analytical Chemistry, 88, 4269-4276 (2016) (link)

Stoichiometry and assembly of mTOR complexes revealed by single-molecule pulldown
Jain A*, Arauz E*, Aggarwal V, Ikon N, Chen J, Ha T, Proceedings of the National Academy of Sciences, 111, 17833-17838 (2014) (link) *equal contribution

An improved surface passivation method for single-molecule studies
Hua B, Han K, Zhou R, Kim H, Shi X, Abeysirigunawardena S, Jain A, Singh D, Aggarwal V, Woodson S, Ha T, Nature Methods, 11, 1233-1236 (2014) (link)

Towards a computational model of a methane producing archaeum
Peterson J, Labhsetwar P, Ellermeier J, Kohler P, Jain A, Ha T, Metcalf W, Luthey-Schulten Z, Archaea, Article ID 898453 (2014)

ATPase-driven oligomerization of RIG-I on RNA allows optimal activation of type-I interferon
Patel J, Jain A, Chou Y, Baum A, Ha T, García-Sastre A. EMBO reports (link)

Dynamics of major histocompatibility complex class I association with the human peptide-loading complex
Panter M, Jain A, Leonhard R, Ha T, Cresswell P, Journal of Biological Chemistry, 287, 31172-31184 (2012)

Dynamic association of ORCA with pre-RC components regulates DNA replication initiation
Shen Z, Chakraborty A, Jain A, Giri S, Ha T, Prasanth KV, Prasanth SG, Molecular and Cellular Biology, 32, 3107-3120 (2012)

Single-molecule pull-down for studying protein interactions
Jain A, Liu R, Xiang Y, Ha T, Nature Protocols, 7, 445–452 (2012)

An entirely specific type I A-kinase anchoring protein that can sequester two molecules of PKA at mitochondria
Means C, Lygren B, Langeberg L, Jain A, Dixon R, Vega A, Gold M, Petrosyan S, Taylor S, Murphy A, Ha T, Santana L, Tasken K, Scott J, Proceedings of the National Academy of Sciences, 108, E1227-E1235 (2011)

Probing cellular protein complexes using single-molecule pull-down
Jain A, Liu R, Ramani B, Arauz E, Ishitsuka Y, Ragunathan K, Park J, Chen J, Xiang Y, Ha T, Nature, 473, 484-488 (2011) (link)
News highlights by Nature, Nature Methods, Nature Biotechnology, BioTechniques, Faculty1000

Structures, ionization equilibria and tautomerism of 6-oxopurines in solution
Gogia S, Jain A, Puranik M, Journal of Physical Chemistry B, 113, 15101-15118 (2009)

Fluorescence lifetime spectroscopy and imaging of visible fluorescent proteins
Jain A, Blum C, Subramaniam V, Advances in Biomedical Engineering, 145-174 (ed. Verdonck P.), Elsevier Science (2008)

Helical structures of ESCRT-III are disassembled by VPS4
Lata S, Schoehn G, Jain A, Pires R, Piehler J, Goettlinger H, Weissenhorn W, Science, 321, 1354-1357 (2008)